(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt Hydrate
Rosihlitazone
CAS: 104376-79-6
Molecular Formula: C18H16N8Na2O7S3.31/2H2O
(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt Hydrate - Names and Identifiers
(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt Hydrate - Physico-chemical Properties
| Molecular Formula | C18H16N8Na2O7S3.31/2H2O |
| Molar Mass | 598.54 |
| Melting Point | 236 °C |
| Specific Rotation(α) | D25 -165° (c = 1 in water) (calc for water-free substance) |
| Water Solubility | Freely soluble in water |
| Solubility | H2O: soluble50mg/mL |
| Appearance | powder or crystals |
| Color | White to Off-White |
| pKa | ~3 (COOH), 3.2 (NH3+), 4.1 (enolic OH) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Refractive Index | -160 ° (C=1, H2O) |
| Use | For the treatment of respiratory tract infections, urinary tract infections, gonorrhea and preoperative infection prevention |
| In vitro study | Ceftriaxone sodium trihydrate is a third-generation cephalosporin antibiotic with a broad spectrum of in vitro activity against both Gram-positive and Gram-negative bacteria, aerobic bacteria and some anaerobic bacteria. Both penicillin-sensitive or resistant strains, Staphyococcus aureus, were sensitive to Ceftriaxone (MIC90, 2 to 8 mg/L), but the drug was poorly active against methicillin-or oxacillin-resistant strains. For Streptococcus pyogenes , Creftriaxone has similar antibacterial activity to penicillins and other cephalosporins, and has good activity against other Streptococcus bacteria at low concentrations. Staphylococcus epidermidis was only moderately sensitive to Creftriaxone, whereas Streptococcus faecalis was resistant to Ceftriaxone. The antibacterial activity of Ceftriaxone was generally better than that of cefoperazone against gram-negative bacilli, and was similar to that of cefotaxime and lactamoxifen. Most Enterobacteroacae had 90% of the tested strains inhibited by Ceftriaxone at a concentration of <1 mg/L. The reported inhibitory activity of Creftriaxone against Pseudomonas aeruginosa varies greatly, but usually to inhibit most strains, a concentration of at least 32 mg/L is required, so it is more important for Pseudomonas aeruginosa than aminoglycosides, aztreonam, imipenem, cefoperazone, ceftazidime have low activity. And several other Bacteroides species, including B. fragilis, are moderately sensitive and resistant to Creftriaxone, but other anaerobic bacteria can be inhibited by the drug. Creftriaxone is stable to inactivation by β-lactamases produced by many bacteria, but B. Β-lactamases produced by fragilis or some Klebsiella strains, Proteus vulgaris, and Pseudomonas cepacia cause their inactivation. In general, the β-lactamase stability of Creftriaxone is similar to that of cefotaxime and cefamfuroxime. |
(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt Hydrate - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37 - Wear suitable gloves. S24 - Avoid contact with skin. S22 - Do not breathe dust. |
| UN IDs | 36/37/38-42/43 |
| WGK Germany | 1 |
| RTECS | XI0368800 |
| HS Code | 29349990 |
| Toxicity | LD50 in male, female, mice, rats (mg/kg): 3000, 2800, 2175, 2175 i.v.; >10000 all species orally; >5000 all species s.c. (Teelman) |
(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt Hydrate - Disulfiram-like reaction induced by intravenous infusion of ceftriaxone sodium
from hownet
Author:
Abstract:
patient male, 46 years old. For reason of frequent micturition, urgent micturition and dysuria for 3 days, the patient visited the hospital on February 16, 2004. Physical examination: body temperature 37.4 ℃, lower abdominal tenderness. Laboratory examination: urine routine test: WBC20-30/HP, RBC1-4/HP, BLD( ); Otherwise normal. Diagnosis: urinary tract infection. The patient was given ceftriaxone sodium 2.0g/d ivgtt and was advised not to drink alcohol during the treatment. At 5:00 pm the next day, the patient left for reason of having no medication for the same night.
Key words:
disulfiram-like reaction ceftriaxone sodium sodium chloride injection substructure package insert cefminox cefmetazole dexamethasone cefoperazone urinary tract infection
DOI:
10.3969/j.issn.1008-5734.2005.01.040
cited:
year:
2005
Last Update：2024-01-02 23:10:35
(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt Hydrate - Analysis of 78 cases of adverse drug reactions induced by ceftriaxone sodium
from titanium academic
Author:
Abstract:
Title: ceftriaxene sodium (ceftriaxene) is one of the most widely used third-generation cephalosporins in clinical practice. It has a wide spectrum of antibacterial and good stability to most β-lactamases, longer half-life, especially for Pseudomonas aeruginosa infection. With the increasing use of ceftriaxone sodium in the treatment of patients with severe infections, more and more attention has been paid to adverse reactions. In this paper, the reports of adverse reactions of ceftriaxone sodium provided by ADR center in our hospital in the past two years were statistically analyzed. In order to provide medical and nursing staff medication reference.
DOI:
10.3969/j.issn.1672-8157.2002.04.022
cited:
year:
2002
Last Update：2023-08-16 22:05:47
(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt Hydrate - A case of hypokalemia induced by intravenous drip of ceftriaxone sodium
from VIP Journal Professional Edition
Author:
Zou Yanhong Chen () Bi Xiangjie , Sun Yan
Abstract:
Male, 30 a. On the morning of 12 October 2002, he was admitted with erythema nodosum. Past health. After admission, blood potassium, sodium, chlorine and renal function, urine routine were normal. Ceftriaxone sodium (Sanjiu Group Shenzhen Jiuxin Pharmaceutical Co., Ltd., LOT 020709, 1 g each) 2.0g NS, bid,iv gtt was administered. On the second afternoon of admission, the patient presented with transient weakness of both lower extremities, which was worsening every day. On the 16th of October, the patient presented with transient weakness of all four extremities, give 1.5g KCl NS, iv gtt .Key words:
ivgtt ceftriaxone sodium hypokalemia adverse drug reaction
DOI:
CNKI:SUN:LCZZ.0.2003-05-017
cited:
year:
2003
Last Update：2023-08-16 22:05:47
(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt Hydrate - Clinical Study of Shiwei gentianhua granules combined with ceftriaxone sodium in the treatment of elderly Community Acquired Pneumonia
from VIP
Author:
Abstract:
objective to investigate the clinical efficacy of Shiwei gentianhua granules combined with ceftriaxone sodium in the treatment of elderly Community Acquired Pneumonia. Methods patients (92 cases) with Community Acquired Pneumonia in Shangqiu Fifth People's Hospital from August 2016 to August 2017 were divided into control (46 cases) and treatment (46 cases) groups based on different medication. Patients in the control group were IV administered with ceftriaxone sodium for injection, 2 g added into normal saline 100 mL,2 times/d; Patients in the treatment group were given oral administration of Shiwei gentianhua granules, 3g/time, 3 times/d. Two groups of patients were treated for 7 days. After treatment, the clinical efficacies were evaluated, and the improvement time of clinical symptoms and serological indexes before and after treatment in two groups were compared. Results after treatment, the clinical efficacies in the control and treatment groups were 80.43% and 95.65%, respectively, and there were differences between two groups (P0.05). After treatment, the disappearance time of Fever, Expectoration and Pulmonary rales in the treatment group were significantly shorter than those in the control group, with significant difference between two groups (P0.05). After treatment, the levels of serum C- reactive protein (CRP),N-terminal pro-brain natriuretic peptide (NT-proBNP), tumor necrosis factor-α(TNF-α) and calcitonin (PCT) in two groups were significantly decreased, there was a statistically significant difference between the two groups (P0.05). And the serological indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P0.05). Conclusion Shiwei gentianhua granules combined with ceftriaxone sodium for injection has significant curative effect in treatment of elderly Community Acquired Pneumonia, can effectively improve the clinical symptoms, and reduce the inflammatory response, which has a certain clinical application value.
stowed
Key words:
Ten-flavor gentian flower granules ceftriaxone sodium for injection Community Acquired Pneumonia clinical efficacy N-terminal pro-brain natriuretic peptide calcitonin
DOI:
10.7501/j.issn.1674-5515.2018.04.021
cited:
year:
2018
Last Update：2023-08-16 22:05:47
(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt Hydrate - Determination of ceftriaxone sodium by spectrophotometry
from hownet
Author:
Abstract:
A new spectrophotometric method was established by studying the reaction between ceftriaxone sodium and Fe3 + and determining the optimal reaction conditions. Ceftriaxone sodium and Fe3 + can form a stable complex at room temperature, the complex has a maximum absorption at 470 nm, the apparent molar absorptivity was 1.5 × 103 L/(mol · cm), and the linear range was 0.05-0.60 mg/L. The method was applied to the determination of ceftriaxone sodium, and the results were basically consistent with those obtained by Chinese Pharmacopoeia method. The relative standard deviation was 0.63%, and the recovery was 99.2%-99.5%.
Key words:
spectrophotometry ceftriaxone sodium Fe3+
DOI:
10.3969/j.issn.1007-9432.2005.04.031
cited:
year:
2005
Last Update：2023-08-16 22:05:47
![(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt Hydrate](http://res.chembk.com/assets/str/2d/1/10/104376-79-6.png)
Supplier List
Product Name: Rosihlitazone Request for quotation
CAS: 104376-79-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 104376-79-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Ceftriaxone sodium Visit Supplier Webpage Request for quotationCAS: 104376-79-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Rosihlitazone Request for quotation
CAS: 104376-79-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 104376-79-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Ceftriaxone sodium Visit Supplier Webpage Request for quotationCAS: 104376-79-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History